Test it and see-that's the best way. Depends on a LOT of variables. That said, the factory Moabs hold a bead better than any other wheel I've run. I regularly go to 8psi and do fine. At 6 psi however, it gets dicey as to whether or not I'll blow a bead. Mountainous terrain, lots of ledges, roots, rocks, etc, very steep and very off-camber. In sand or snow, I'll just pull the stem and wait for them to inhale air, then go. Sand/snow is very forgiving for air. If you do blow a bead, Co2 works great, as does any air source, even a bike pump in a pinch if need be-though it will take a LOT of pumping to get it to seat.
Best of Luck,
Mike
Best of Luck,
Mike